Ashwagandha, also known as Withania somnifera or winter cherry, may be a powerful anti-aging ingredient by boosting immune system function and providing antioxidant benefits, according to a review published in Frontiers in Nutrition. Preclinical studies suggest that compounds in ashwagandha can modulate gene expression in cells, potentially addressing immunity and aging-related conditions like long Covid and Alzheimer’s disease.
Aging and Nutraceuticals
Aging is a complex and progressive process affecting various bodily systems at cellular and molecular levels. The review, led by Sujit Nair from PhytoVeda Pvt. Ltd in Mumbai, India, discusses how nutraceutical interventions, including ashwagandha, could slow the aging process by modulating gene transcription linked to aging and related complications. The global rise in age-related conditions underscores the importance of preventative strategies, the study authors noted.
Biological Mechanisms and Benefits
Ashwagandha, an evergreen shrub native to the Middle East, Africa, and Asia, contains active compounds like withaferin A, withanolide, and withanone. These compounds exhibit antioxidant and immunomodulatory properties and could play a role in mitigating RNA-level changes associated with aging. The plant has shown promise in human cell culture studies for addressing aging-related conditions by reducing inflammatory markers, potentially aiding in the treatment of long Covid and slowing Alzheimer’s disease progression. It may also benefit conditions such as gastrointestinal ulcers, breast cancer, and asthma.
Current Research and Future Directions
While ashwagandha has been commercialized as a dietary supplement, research into its role in promoting healthy aging is still in early stages. Clinical trials have attempted to demonstrate its benefits, focusing on biomarkers like inflammatory markers and indicators of stress, anxiety, and endurance. However, the results from these trials are limited and often not peer-reviewed, highlighting the need for more robust evidence.
Nair’s team is currently conducting a clinical trial on ashwagandha’s effects on aging, with results expected soon. The key goals include establishing a scientific basis for its use and ensuring consistent quality in manufacturing. Additionally, understanding the precise biological mechanisms by which ashwagandha influences aging hallmarks is crucial. The main challenge in using nutraceuticals is finding a comprehensive solution for all aspects of aging and determining the optimal dosage and duration for therapy.
Ashwagandha shows tremendous potential for promoting healthy aging by modulating key RNA markers and inflammation pathways. As research progresses, it may become a valuable tool in the quest to manage and slow the aging process, offering hope for improved health and longevity.